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Rheumatology

EGPA

Classification

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis


Clinical criteria

Obstructive airway disease

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Nasal polyps

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Mononeuritis multiplex

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Laboratory and biopsy criteria

Blood eosinophil count > 1 x109/litre

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Extravascular eosinophilic-predominant inflammation on biopsy

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Positive test for cytoplasmic antineutrophil cytoplasmic antibodies (cANCA) or antiproteinase 3 (anti-PR3) antibodies

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Haematuria

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Considerations

The tool is for educational use only, is not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

  • These classification criteria should be applied to classify a patient as having eosinophilic granulomatosis with polyangiitis when a diagnosis of small- or medium-vessel vasculitis has been made
  • Alternate diagnoses mimicking vasculitis should be excluded prior to applying the criteria
Reference

Grayson PC, Ponte C, Suppiah R, et al 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis Annals of the Rheumatic Diseases Published Online First: 02 February 2022. doi: 10.1136/annrheumdis-2021-221794

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